Barta Z, Szabó G G, Illés A, Szegedi G
Debreceni Orvostudományi Egyetem, III. Belgyógyászati Klinika.
Orv Hetil. 1998 Mar 8;139(10):569-72.
The authors survey the literature of Whipple's disease and present two of their patients. They assure that Whipple's disease in either associated with or is a result of an immunopathological clinical picture, but it is else possible that assumed pathogen, the Tropheryma whippleii itself alters the immune system. In the case of their female patient with active disease they showed the rearrangement of the bcl-2 gene [t(14; 18)] in her peripheral blood lymphocytes, while in their male patient in remission this could not be proved. During the observation, in their female patient insulin dependent diabetes mellitus (IDDM) developed. In connection with these cases, the authors draw the attention to the varied symptoms which are characteristic of autoimmune disease, and to the immunoserological laboratory differences in particular the rearrangement of the bcl-2 gene.
作者对惠普尔病的文献进行了综述，并介绍了他们的两名患者。他们确信惠普尔病要么与免疫病理临床表现相关，要么是其结果，但也有可能假定的病原体——惠普尔氏嗜组织菌本身会改变免疫系统。在他们患有活动性疾病的女性患者中，他们发现其外周血淋巴细胞中存在bcl-2基因重排[t(14; 18)]，而在处于缓解期的男性患者中未得到证实。在观察期间，他们的女性患者发展为胰岛素依赖型糖尿病（IDDM）。结合这些病例，作者提请注意自身免疫性疾病特有的各种症状，以及免疫血清学实验室差异，特别是bcl-2基因的重排。
