晚期胃肠道癌大剂量每周 5-氟尿嘧啶与甲环亚硝脲加每周大剂量 5-氟尿嘧啶治疗的 III 期比较。一项西南肿瘤协作组的研究。
Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU vs. methyl-CCNU plus bolus weekly 5-FU. A Southwest Oncology Group study.
作者信息
Baker L H, Talley R W, Matter R, Lehane D E, Ruffner B W, Jones S E, Morrison F S, Stephens R L, Gehan E A, Vaitkevicius V K
出版信息
Cancer. 1976 Jul;38(1):1-7. doi: 10.1002/1097-0142(197607)38:1<1::aid-cncr2820380102>3.0.co;2-s.
In a randomized and stratified study, 294 patients with advanced gastrointestinal cancer were treated either with 5-fluorouracil (5-FU) 400 mg/m2 weekly intravenously (i.v.) or 5-FU 400 mg/m2 i.v. weekly plus methyl-CCNU 175 mg/m2 orally (p.o.) every 6 weeks. The response rate in colorectal cancer with 5-FU was 9.5% while the two-drug treatment produced a response of 31.8% (p=.009). The response in all gastrointestinal cancers to 5-FU was 10.6% as compared with29.3% for the combination (p=.012). All responses were partial. The two-drug regimen is more effective and more toxic than weekly 5-FU therapy.
在一项随机分层研究中，294例晚期胃肠道癌患者接受了以下治疗：要么静脉注射5-氟尿嘧啶（5-FU）400mg/m²，每周一次；要么静脉注射5-FU 400mg/m²，每周一次，同时每6周口服甲基环己亚硝脲175mg/m²。5-FU单药治疗结直肠癌的缓解率为9.5%，而两药联合治疗的缓解率为31.8%（p = 0.009）。5-FU单药治疗所有胃肠道癌的缓解率为10.6%，联合治疗为29.3%（p = 0.012）。所有缓解均为部分缓解。两药联合方案比每周一次的5-FU治疗更有效，但毒性也更大。
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