c-ANCA在韦格纳肉芽肿中的诊断效用。

The diagnostic utility of c-ANCA in Wegener's granulomatosis.

作者信息

Langford C A

机构信息

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

出版信息

Cleve Clin J Med. 1998 Mar;65(3):135-40. doi: 10.3949/ccjm.65.3.135.

DOI:10.3949/ccjm.65.3.135

PMID:9540246

Abstract

Anti-neutrophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA) have been found to have a high degree of sensitivity and specificity for Wegener's granulomatosis. Nevertheless, despite the attraction of using this autoantibody as a diagnostic test, in almost all instances it should not be used in place of a biopsy to diagnose Wegener's granulomatosis.

摘要

发现具有胞浆染色模式的抗中性粒细胞胞浆抗体（c-ANCA）对韦格纳肉芽肿具有高度的敏感性和特异性。然而，尽管使用这种自身抗体作为诊断测试很有吸引力，但在几乎所有情况下，都不应将其用于替代活检来诊断韦格纳肉芽肿。