外阴前庭炎综合征中的前庭神经纤维增生

Vestibular nerve fiber proliferation in vulvar vestibulitis syndrome.

作者信息

Weström L V, Willén R

机构信息

Institute of Obstetrics and Gynecology, University of Lund, University Hospital, Sweden.

出版信息

Obstet Gynecol. 1998 Apr;91(4):572-6.

PMID:9540943

Abstract

OBJECTIVE

To evaluate nerve fiber density in vestibular specimens from women operated upon for vulvar vestibulitis.

METHODS

Forty-seven women with vulvar vestibulitis syndrome underwent modified posterior vestibulectomies. Vestibular specimens were analyzed after being stained for S-100 neural tissue protein. Women were followed up for 2 years.

RESULTS

In specimens from 44 of 47 patients, the densities and numbers of nerve fibers per square unit in the preparations were greater than those in specimens from six control women. In the patients, a statistically significant linear correlation was found between inflammation and nerve bundle density in the preparations (Spearman rank correlation coefficient rs=.41; P=.005). There were no signs of infectious etiology in any preparation. No or slight postoperative dyspareunia was reported by 38 of 42 women after 6 months, 36 of 39 after 12 months, and 26 of 28 after 24 months.

CONCLUSION

Vestibular neural hyperplasia may provide a morphologic explanation of the pain in vulvar vestibulitis syndrome.

摘要

目的

评估因外阴前庭炎接受手术的女性前庭标本中的神经纤维密度。

方法

47例患有外阴前庭炎综合征的女性接受了改良后的前庭切除术。对前庭标本进行S-100神经组织蛋白染色后进行分析。对这些女性进行了2年的随访。

结果

47例患者中44例的标本中，每平方单位制剂中的神经纤维密度和数量高于6名对照女性的标本。在患者中，制剂中的炎症与神经束密度之间存在统计学上显著的线性相关性（Spearman等级相关系数rs = 0.41；P = 0.005）。任何制剂中均未发现感染病因的迹象。42例女性中有38例在6个月后、39例中有3在12个月后、28例中有26例在24个月后报告无或仅有轻微的术后性交困难。