Reimund J M, Allison A C, Muller C D, Dumont S, Kenney J S, Baumann R, Duclos B, Poindron P
Centre de Recherches Pharmacologiques, Illkirch-Graffenstaden, France.
Eur J Clin Invest. 1998 Feb;28(2):145-50. doi: 10.1046/j.1365-2362.1998.00257.x.
Modulation of cytokine secretion may be of interest in the treatment of Crohn's disease or ulcerative colitis.
The effect of three antioxidants - butylated hydroxyanisol, tetrahydropapaveroline and nordihydroguaiaretic acid - on the production of tumour necrosis factor (TNF), interleukin (IL) 1, IL-6 and IL-8 (measured by enzyme-linked immunosorbent assay) by peripheral mononuclear cells and biopsies of inflamed colonic mucosa from inflammatory bowel disease patients were studied.
We observed a decrease in IL-1 and IL-6 production by peripheral mononuclear cells from inflammatory bowel disease patients (approximately 50% of control). The three drugs did not decrease IL-6 and IL-8 secretion by colonic biopsies, whereas they did inhibit IL-1 and, to some degree, TNF production. The cytokine-inhibitory effect of antioxidants seems to be more pronounced in ulcerative colitis than in Crohn's disease.
Our results suggest that the studied antioxidants, or related compounds, may be of interest in inflammatory bowel disease treatment.
细胞因子分泌的调节可能在克罗恩病或溃疡性结肠炎的治疗中具有重要意义。
研究了三种抗氧化剂——叔丁基对羟基茴香醚、四氢罂粟碱和去甲二氢愈创木酸——对炎症性肠病患者外周单核细胞和炎症性结肠黏膜活检组织中肿瘤坏死因子（TNF）、白细胞介素（IL）-1、IL-6和IL-8产生的影响（通过酶联免疫吸附测定法测量）。
我们观察到炎症性肠病患者外周单核细胞中IL-1和IL-6的产生减少（约为对照组的50%）。这三种药物并未降低结肠活检组织中IL-6和IL-8的分泌，但它们确实抑制了IL-1，并在一定程度上抑制了TNF的产生。抗氧化剂对细胞因子的抑制作用在溃疡性结肠炎中似乎比在克罗恩病中更为明显。
我们的结果表明，所研究的抗氧化剂或相关化合物可能在炎症性肠病的治疗中具有重要意义。
