牙齿发育过程中的激活素与骨形态发生蛋白（BMP）信号传导

Activin and bone morphogenetic protein (BMP) signalling during tooth development.

作者信息

Heikinheimo K, Bègue-Kirn C, Ritvos O, Tuuri T, Ruch J V

机构信息

Institute of Dentistry, University of Turku, Finland.

出版信息

Eur J Oral Sci. 1998 Jan;106 Suppl 1:167-73. doi: 10.1111/j.1600-0722.1998.tb02171.x.

DOI:10.1111/j.1600-0722.1998.tb02171.x

PMID:9541221

Abstract

Activins and bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related cytokines. Results of recent in vivo and in vitro studies suggest that activin A, several BMPs, and their cell surface receptors may participate in tooth development. In addition, follistatin an extracellular protein that may interact with activin and BMP signaling, appears to be involved. This review focuses on recent advances in relation to the roles of activin/BMP receptors, their ligands and extracellular modifiers during tooth development.

摘要

激活素和骨形态发生蛋白（BMPs）属于结构相关细胞因子的转化生长因子-β（TGF-β）超家族。近期体内和体外研究结果表明，激活素A、几种骨形态发生蛋白及其细胞表面受体可能参与牙齿发育。此外，卵泡抑素（一种可能与激活素和骨形态发生蛋白信号传导相互作用的细胞外蛋白）似乎也参与其中。本综述重点关注激活素/骨形态发生蛋白受体、其配体和细胞外调节因子在牙齿发育过程中的作用的最新进展。