营养不良儿童的QT间期离散度
QT-interval dispersion in malnourished children.
作者信息
Fuenmayor A J, Mora R E, Fuenmayor A C, Fuenmayor A M
机构信息
Cardiovascular Research Center, University of The Andes, Mérida, Venezuela.
出版信息
Clin Cardiol. 1998 Mar;21(3):201-5. doi: 10.1002/clc.4960210313.
BACKGROUND
Little is known about the electrocardiographic (ECG) QT interval and its variability in malnourished children.
HYPOTHESIS
The study of the QT interval and its dispersion in malnourished children was undertaken to determine whether the QT interval and its variability are increased in these children.
METHODS
In 40 children (20 malnourished and 20 controls) aged 12.2 +/- 14.4 months (23 male) a conventional ECG was performed for computing heart rate, heart rate variability, corrected QT interval, and QT-interval dispersion. A blood sample was obtained for measuring hemoglobin, hematocrit, plasma protein, and plasma electrolytic concentrations.
RESULTS
Corrected heart rate, heart rate variability, and QT Interval were similar in both groups. When compared with the control group, the malnourished children had greater corrected QT-interval dispersion, and that dispersion was more accentuated in the precordial leads. They also had repolarization abnormalities (flattened or inverted T waves and U waves). Hemoglobin, hematocrit, plasma protein, and plasma electrolytic concentrations were lower in the malnourished children. However, the ECG findings showed no statistically significant relationship with either the blood parameters, the severity or type of malnutrition, and the size or the weight of the children.
CONCLUSIONS
QT-interval dispersion is increased in malnourished children and the dispersion is more accentuated in the precordial leads.
背景
关于营养不良儿童的心电图（ECG）QT间期及其变异性，人们了解甚少。
假设
对营养不良儿童的QT间期及其离散度进行研究，以确定这些儿童的QT间期及其变异性是否增加。
方法
对40名年龄为12.2±14.4个月（23名男性）的儿童（20名营养不良儿童和20名对照儿童）进行常规心电图检查，以计算心率、心率变异性、校正QT间期和QT间期离散度。采集血样以测量血红蛋白、血细胞比容、血浆蛋白和血浆电解质浓度。
结果
两组的校正心率、心率变异性和QT间期相似。与对照组相比，营养不良儿童的校正QT间期离散度更大，且这种离散度在胸前导联更为明显。他们还存在复极异常（T波平坦或倒置以及U波）。营养不良儿童的血红蛋白、血细胞比容、血浆蛋白和血浆电解质浓度较低。然而，心电图结果与血液参数、营养不良的严重程度或类型以及儿童的身高或体重均无统计学上的显著关系。
结论
营养不良儿童的QT间期离散度增加，且在胸前导联更为明显。
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