Berg K, Hames C, Dahlén G, Frick M H, Krishan I
Clin Genet. 1976 Aug;10(2NA-NA-760903-760909):97-103. doi: 10.1111/j.1399-0004.1976.tb00020.x.
Analyses of 12 population samples have revealed that the total serum cholesterol level is significantly higher in Lp(a +) than in Lp(a -) individuals. The difference is more pronounced in middle-aged and other people than in young persons, and the difference between Lp(a +) and Lp(a -) individuals is larger when LDL cholesterol rather than total serum cholesterol is considered. Lp(a -) individuals have a significantly higher triglyceride level than Lp(a +) individuals. The Lp(a) variation is genetically controlled. Thus, the present study has revealed a small but significant effect of a single, autosomal locus on lipids implicated in atherosclerosis. An association between the phenotype Lp(a +) and coronary heart disease has been demonstrated previously.
对12个群体样本的分析表明，Lp(a+)个体的血清总胆固醇水平显著高于Lp(a-)个体。这种差异在中年人和其他人群中比在年轻人中更为明显，并且当考虑低密度脂蛋白胆固醇而非血清总胆固醇时，Lp(a+)和Lp(a-)个体之间的差异更大。Lp(a-)个体的甘油三酯水平显著高于Lp(a+)个体。Lp(a)的变异受基因控制。因此，本研究揭示了一个单一的常染色体基因座对涉及动脉粥样硬化的脂质有微小但显著的影响。此前已证明Lp(a+)表型与冠心病之间存在关联。
