Dahlén G, Berg K, Frick M H
Clin Genet. 1976 Jun;9(6):558-66. doi: 10.1111/j.1399-0004.1976.tb01613.x.
With appropriate electrophoretic techniques and fresh serum samples, the Lp(a) lipoprotein/pre-beta1-lipoprotein is demonstrable as a distinct zone in the area between beta-lipoprotein and ordinary pre-beta-lipoprotein, when sera which are strongly positive with respect to the Lp(a) antigen are analyzed. The Lp(a) lipoprotein is a genetically determined normal serum component. The phenotype Lp(a+) was found significantly more frequently in two series of patients with coronary heart disease (CHD) than in appropriate controls. The frequency difference between patients and controls was particularly pronounced for the Finnish samples studied, 55% of the patients having the phenotype Lp(a+), as opposed to only 31% of the healthy controls. As judged from electrophoresis strips, hibh concentrations of Lp(a) lipoprotein/pre-beta1-lipoprotein were positively correlated with coronary score as determined by angiography. This correlation was highly significant. Total serum cholesterol value was slightly higher in Lp(a+) than in Lp(a-) persons from two of the four population samples studied, but no statistically significant difference was found. Serum triglyceride levels exhibited a statistically insignificant trend towards higher values in Lp(a-) than in Lp(a+) individuals, in three of the four samples tested. The strong association between the phenotype Lp(a+) and CHD, as well as the correlation between high amounts of Lp(a) lipoprotein/pre-beta1-lipoprotein and coronary score on one hand, and the weak correlation between presence of Lp(a) lipoprotein/pre-beta1-lipoprotein and lipid values on the other, make it highly unlikely that the increased frequency of the Lp(a+) phenotype in CHD patients merely reflects an over-all increase of the intravascular pool of LDL and/or VLDL reflected in increased serum levels of cholesterol and/or triglycerides. By the same token, it is unlikely that the insignificant effect on lipid values can, on its own, explain the correlation between Lp(a) phenotype and CHD.
采用适当的电泳技术和新鲜血清样本，当分析对Lp(a)抗原呈强阳性的血清时，Lp(a)脂蛋白/前β1-脂蛋白可在β-脂蛋白和普通前β-脂蛋白之间的区域显示为一个独特的区带。Lp(a)脂蛋白是一种由遗传决定的正常血清成分。在两组冠心病（CHD）患者中发现Lp(a+)表型的频率明显高于相应的对照组。在所研究的芬兰样本中，患者与对照组之间的频率差异尤为明显，55%的患者具有Lp(a+)表型，而健康对照组仅为31%。从电泳条带判断，Lp(a)脂蛋白/前β1-脂蛋白的高浓度与血管造影确定的冠状动脉积分呈正相关。这种相关性非常显著。在所研究的四个人口样本中的两个样本中，Lp(a+)者的总血清胆固醇值略高于Lp(a-)者，但未发现统计学上的显著差异。在四个测试样本中的三个样本中，血清甘油三酯水平在Lp(a-)个体中比在Lp(a+)个体中呈现出无统计学意义的更高值趋势。Lp(a+)表型与冠心病之间的强关联，以及一方面Lp(a)脂蛋白/前β1-脂蛋白的高含量与冠状动脉积分之间的相关性，另一方面Lp(a)脂蛋白/前β1-脂蛋白的存在与血脂值之间的弱相关性，使得冠心病患者中Lp(a+)表型频率的增加仅仅反映胆固醇和/或甘油三酯血清水平升高所反映的血管内低密度脂蛋白（LDL）和/或极低密度脂蛋白（VLDL）池的总体增加的可能性极小。同样，血脂值上的不显著影响本身也不太可能解释Lp(a)表型与冠心病之间的相关性。
