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1
Genetic variation in serum low density lipoproteins and lipid levels in man.人类血清低密度脂蛋白的遗传变异与血脂水平
Proc Natl Acad Sci U S A. 1976 Mar;73(3):937-40. doi: 10.1073/pnas.73.3.937.
2
Associations of oral contraceptive use with serum lipids and lipoproteins in young women: the Bogalusa Heart Study.年轻女性口服避孕药使用与血清脂质和脂蛋白的关联：博加卢萨心脏研究
Ann Epidemiol. 1997 Nov;7(8):561-7. doi: 10.1016/s1047-2797(97)00119-1.
3
Nutrient intake: relationships with lipids and lipoproteins in 6--19-year-old children--the Princeton School District study.营养摄入：普林斯顿学区6至19岁儿童与脂质及脂蛋白的关系研究
Metabolism. 1980 Feb;29(2):133-40. doi: 10.1016/0026-0495(80)90137-7.
4
HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study.高密度脂蛋白胆固醇及其他脂质与冠心病。合作脂蛋白表型研究。
Circulation. 1977 May;55(5):767-72. doi: 10.1161/01.cir.55.5.767.
5
Lipid and lipoprotein distributions in black adults. The Cincinnati Lipid Research Clinic's Princeton School Study.黑人成年人的脂质和脂蛋白分布。辛辛那提脂质研究诊所普林斯顿学校研究。
JAMA. 1981 Mar 6;245(9):939-42.
6
Genetic lipoprotein variation and lipid levels in man.人类的遗传性脂蛋白变异与血脂水平
Clin Genet. 1976 Aug;10(2NA-NA-760903-760909):97-103. doi: 10.1111/j.1399-0004.1976.tb00020.x.
7
Lipid composition and interrelationships of major serum lipoproteins. Observations in children with different lipoprotein profiles. Bogalusa Heart Study.主要血清脂蛋白的脂质组成及相互关系。不同脂蛋白谱儿童的观察结果。博加卢萨心脏研究。
Arteriosclerosis. 1982 Jul-Aug;2(4):335-45. doi: 10.1161/01.atv.2.4.335.
8
Lipoprotein heterogeneity at birth: influence of gestational age and race on lipoprotein subclasses and Lp (a) lipoprotein.出生时脂蛋白的异质性：胎龄和种族对脂蛋白亚类及脂蛋白(a)的影响。
Ethn Dis. 2004 Summer;14(3):351-9.
9
Relation of cholesterol to apolipoprotein B in low density lipoproteins of children. The Bogalusa Heart Study.儿童低密度脂蛋白中胆固醇与载脂蛋白B的关系。博加卢萨心脏研究。
Arteriosclerosis. 1989 Jul-Aug;9(4):493-500. doi: 10.1161/01.atv.9.4.493.
10
Race and gender differences in serum lipoproteins of children, adolescents, and young adults--emergence of an adverse lipoprotein pattern in white males: the Bogalusa Heart Study.儿童、青少年及青年血清脂蛋白的种族和性别差异——白人男性中不良脂蛋白模式的出现：博加卢萨心脏研究
Prev Med. 1991 Nov;20(6):671-84. doi: 10.1016/0091-7435(91)90063-a.

引用本文的文献

1
Polymorphisms of the apolipoprotein B and E genes and their relationship to plasma lipid variables in healthy Chinese men.中国健康男性载脂蛋白B和E基因多态性及其与血脂变量的关系
Hum Genet. 1993 Sep;92(2):191-7. doi: 10.1007/BF00219691.
2
Polymorphisms in the apolipoprotein B-100 gene contributes to normal variation in plasma lipids in 464 Danish men born in 1948.载脂蛋白B - 100基因多态性对1948年出生的464名丹麦男性血浆脂质的正常变异有影响。
Hum Genet. 1993 Mar;91(1):45-50. doi: 10.1007/BF00230221.
3
Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings.检测狒狒脂蛋白表型的遗传效应：方法综述与初步研究结果
Genetica. 1987 Aug 31;73(1-2):159-68. doi: 10.1007/BF00057446.
4
Inheritance of low-density lipoprotein subclass patterns: results of complex segregation analysis.低密度脂蛋白亚类模式的遗传：复杂分离分析结果
Am J Hum Genet. 1988 Dec;43(6):838-46.
5
Genetic linkage between the antigenic group (Ag) variation and the apolipoprotein B gene: assignment of the Ag locus.抗原组（Ag）变异与载脂蛋白B基因之间的遗传连锁：Ag位点的定位
Proc Natl Acad Sci U S A. 1986 Oct;83(19):7367-70. doi: 10.1073/pnas.83.19.7367.
6
Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100.一种特定载脂蛋白B突变与家族性缺陷载脂蛋白B-100之间的关联。
Proc Natl Acad Sci U S A. 1989 Jan;86(2):587-91. doi: 10.1073/pnas.86.2.587.
7
Apolipoprotein B amino acid 3611 substitution from arginine to glutamine creates the Ag (h/i) epitope: the polymorphism is not associated with differences in serum cholesterol and apolipoprotein B levels.载脂蛋白B第3611位氨基酸由精氨酸替换为谷氨酰胺产生Ag(h/i)表位：该多态性与血清胆固醇和载脂蛋白B水平的差异无关。
Hum Genet. 1989 Jul;82(4):322-6. doi: 10.1007/BF00273990.
8
Relationships between DNA and protein polymorphisms of apolipoprotein B.载脂蛋白B的DNA与蛋白质多态性之间的关系。
Hum Genet. 1988 Apr;78(4):325-9. doi: 10.1007/BF00291728.
9
A worldwide population study of the Ag-system haplotypes, a genetic polymorphism of human low-density lipoprotein.一项关于Ag系统单倍型（人类低密度脂蛋白的一种基因多态性）的全球人群研究。
Am J Hum Genet. 1990 Mar;46(3):502-17.
10
The polymorphism ApoB/4311 in patients with myocardial infarction and controls: the ECTIM Study.
Hum Genet. 1992 May;89(2):169-75. doi: 10.1007/BF00217118.

本文引用的文献

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Antigen polymorphism of a low-density beta-lipoprotein. Allotypy in human serum.低密度β脂蛋白的抗原多态性。人血清中的同种异型。
Nature. 1962 May 19;194:656-8. doi: 10.1038/194656a0.
2
An isoprecipitation reaction distinguishing human serum-protein types.一种区分人血清蛋白类型的同相沉淀反应。
Lancet. 1961 Mar 25;1(7178):634-7. doi: 10.1016/s0140-6736(61)91654-3.
3
Serum lipoprotein allotypes in man.人类血清脂蛋白别型
Prog Med Genet. 1965;4:176-201.
4
Classification of hyperlipidaemias and hyperlipoproteinaemias.高脂血症和高脂蛋白血症的分类。
Bull World Health Organ. 1970;43(6):891-915.
5
Lp(a) lipoprotein and pre-beta1-lipoprotein in patients with coronary heart disease.冠心病患者中的脂蛋白(a)和前β1-脂蛋白。
Clin Genet. 1974;6(3):230-5. doi: 10.1111/j.1399-0004.1974.tb00657.x.
6
A genetic determinant of the phenotypic variance of the molecular weight of low density lipoprotein.低密度脂蛋白分子量表型变异的遗传决定因素。
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2347-51. doi: 10.1073/pnas.72.6.2347.
7
Lp(a) lipoprotein/pre-beta1-lipoprotein in Swedish middle-aged males and in patients with coronary heart disease.瑞典中年男性和冠心病患者中的脂蛋白（a）/前β1脂蛋白
Clin Genet. 1975 Apr;7(4):334-41. doi: 10.1111/j.1399-0004.1975.tb00338.x.

人类血清低密度脂蛋白的遗传变异与血脂水平

Genetic variation in serum low density lipoproteins and lipid levels in man.

作者信息

Berg K, Hames C, Dahlén G, Frick M H, Krishan I

出版信息

Proc Natl Acad Sci U S A. 1976 Mar;73(3):937-40. doi: 10.1073/pnas.73.3.937.

DOI:10.1073/pnas.73.3.937
PMID:176662
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC336035/
Abstract

Combined data from 10 different populations indicate that the serum cholesterol and triglyceride levels are higher in Ag(x-) than in Ag(x+) individuals. Although the differences were relatively small, they became more pronounced with increasing age. The Ag(x) antigen, which is associated with the serum low density lipoprotein, is genetically controlled and the present study therefore has revealed a small but significant effect of a single autosomal locus on lipids implicated in the pathogenesis of atherosclerosis. No explanation of the higher cholesterol and triglyceride levels in Ag(x-) than in Ag(x+) persons is apparent.

摘要

来自10个不同人群的综合数据表明，Ag(x-)个体的血清胆固醇和甘油三酯水平高于Ag(x+)个体。尽管差异相对较小，但随着年龄的增长，差异变得更加明显。与血清低密度脂蛋白相关的Ag(x)抗原受基因控制，因此本研究揭示了一个常染色体位点对参与动脉粥样硬化发病机制的脂质有微小但显著的影响。目前尚不清楚Ag(x-)个体的胆固醇和甘油三酯水平高于Ag(x+)个体的原因。