Remuzzi G, Bertani T, Mecca G, Donati M B, de Gaetano G
Br Med J. 1978 Jan 14;1(6105):70-2. doi: 10.1136/bmj.1.6105.70.
To determine whether the prolonged bleeding time so common to chronic renal failure (CRF) was due to defective factor VIII-related activities, as in von Willebrand's disease, vascular-factor VIII-related protein was measured in patients with CRF. Factor VIII-related protein was detected by immunofluorescence on the vascular intima of all 13 patients with CRF and greatly prolonged bleeding times. This protein was also present on the vascular intima of a patient with CRF and moderate von Willebrand's disease. These findings support a previous suggestion that the disturbed haemostasis in patients with CRF is not linked to defective factor VIII-related activities.
为了确定慢性肾衰竭（CRF）中常见的出血时间延长是否像血管性血友病那样是由于Ⅷ因子相关活性缺陷所致，对CRF患者的血管性Ⅷ因子相关蛋白进行了检测。通过免疫荧光法在13例CRF且出血时间极长的患者的血管内膜上检测到了Ⅷ因子相关蛋白。在1例患有CRF和中度血管性血友病的患者的血管内膜上也发现了这种蛋白。这些发现支持了之前的一种观点，即CRF患者止血功能紊乱与Ⅷ因子相关活性缺陷无关。
