Eckert C, Olinsky S, Cummins J, Stephan D, Narayanan V
Children's Hospital of Pittsburgh, Pennsylvania, USA.
Somat Cell Mol Genet. 1997 Jul;23(4):297-301. doi: 10.1007/BF02674421.
P84 is a novel neural adhesion molecule that may play an important role in synaptogenesis. We have recently cloned a murine cDNA encoding the P84 adhesion molecule. The human homologue of P84 has previously been isolated (by others) as a brain specific cDNA containing CCA repeats. We have mapped the human P84 gene to the subtelomeric region of chromosome 20p (20p13) by FISH. In addition, we have been able to place P84 onto the high resolution physical map of the human genome by utilizing the Unigene database. P84 maps to several YAC clones, between STS markers IB255 and WI-9632, and very close to the polymorphic marker D20S199, in an interval of less than 1 Mb on 20p13. P84 is a strong candidate gene for neurological disorders which map into this region.
P84是一种新型神经粘附分子，可能在突触形成中发挥重要作用。我们最近克隆了编码P84粘附分子的小鼠cDNA。P84的人类同源物先前已（由其他人）作为含有CCA重复序列的脑特异性cDNA分离出来。我们通过荧光原位杂交（FISH）将人类P84基因定位到20号染色体短臂（20p13）的亚端粒区域。此外，我们利用Unigene数据库将P84定位到人类基因组的高分辨率物理图谱上。P84定位于几个酵母人工染色体（YAC）克隆，位于STS标记IB255和WI - 9632之间，并且非常靠近多态性标记D20S199，在20p13上小于1兆碱基（Mb）的区间内。P84是该区域内定位的神经系统疾病的一个强有力的候选基因。
