Andrésdóttir M B, Assmann K J, Wetzels J F
Afd. Nierziekten, Academisch Ziekenhuis, Nijmegen.
Ned Tijdschr Geneeskd. 1997 Jul 19;141(29):1417-20.
A 51-year-old male patient was treated for a rejection episode after kidney transplantation with horse antithymocyte globulin (ATG). Twelve days after the start of the ATG treatment he developed fever, arthralgia, purpura and acute renal failure. This clinical picture is characteristic of serum sickness, resulting from formation of antibodies to a foreign protein and development of immune complexes. Kidney biopsy revealed an endocapillary glomerulonephritis. Immune complexes probably develop in the mesangium and along the glomerular basal membrane through local formation and precipitation from the circulation. Spontaneous recovery is the rule.
一名51岁男性患者在肾移植后因排斥反应接受马抗胸腺细胞球蛋白（ATG）治疗。ATG治疗开始12天后，他出现发热、关节痛、紫癜和急性肾衰竭。这种临床表现是血清病的特征，是由针对外来蛋白质的抗体形成和免疫复合物的产生所致。肾活检显示毛细血管内增生性肾小球肾炎。免疫复合物可能通过局部形成和从循环中沉淀，在系膜和沿肾小球基底膜形成。通常会自发恢复。
