在初次感染人巨细胞病毒（HCMV）的实体器官移植受者进行抗病毒治疗初期，其HCMV抗原血症水平不断升高。
Rising levels of human cytomegalovirus (HCMV) antigenemia during initial antiviral treatment of solid-organ transplant recipients with primary HCMV infection.
作者信息
Gerna G, Zavattoni M, Percivalle E, Grossi P, Torsellini M, Revello M G
机构信息
Viral Diagnostic Service, IRCCS Policlinico San Matteo, Pavia, Italy.
出版信息
J Clin Microbiol. 1998 Apr;36(4):1113-6. doi: 10.1128/JCM.36.4.1113-1116.1998.
Abstract
In 7 of 18 solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, HCMV antigenemia levels were unexpectedly found to rise significantly (P = 0.018) during a mean time of 7.3 +/- 3.2 days after initiation of specific antiviral treatment, whereas corresponding levels of viremia dropped significantly (P = 0.043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients.
摘要
在18例原发性人巨细胞病毒（HCMV）感染的实体器官移植受者中，有7例在开始特异性抗病毒治疗后的平均7.3±3.2天内，HCMV抗原血症水平意外显著升高（P = 0.018），而相应的病毒血症水平则显著下降（P = 0.043）。因此，仅基于抗原血症水平升高就转而使用另一种抗病毒药物，在这组患者中是不合理的。
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