Thillet J, Doucet C, Chapman J, Herbeth B, Cohen D, Faure-Delanef L
Institut National de la Santé et de la Recherche Medicale, Unité U321, Lipoprotéines et Athérogénèse', Hôpital de la Pitié, Paris, France.
Atherosclerosis. 1998 Feb;136(2):389-94. doi: 10.1016/s0021-9150(97)00217-7.
Epidemiological studies have shown lipoprotein(a) (Lp(a)) to be an independent risk factor for cardiovascular disease. Lp(a) is a cholesterol-rich, low-density lipoprotein (LDL)-like particle to which a large glycoprotein, apolipoprotein(a) (apo(a)) is attached. Plasma Lp(a) levels are highly genetically determined and influenced to a minor degree by environmental factors. In an effort to determine whether Lp(a) might be associated with longevity, we have evaluated Lp(a) levels and apo(a) isoform sizes in a population of French centenarians (n = 109) compared to a control group (n = 227). The mean age of centenarians was 101.5 +/- 2.4 years while the control group was 39.4 +/- 7.2 years. Plasma levels of total cholesterol and triglyceride were within the normal range in both centenarian and control subjects. Lp(a) levels were higher in centenarians (both male and female) than in the normolipidemic control group (mean Lp(a) level = 0.33 +/- 0.42 and 0.22 +/- 0.27 mg/ml, respectively, P < 0.005). The distribution of apo(a) isoforms was significantly shifted towards small isoform size in the centenarian population as compared to the controls (54.4 and 41.4% of isoforms < or = 27 kringles (kr), respectively, P = 0.04). Nonetheless, the apo(a) size distribution in centenarians did not entirely explain the high Lp(a) levels observed in this population. Factors other than apo(a) size, and which may be either genetic or environmental in nature, appear to contribute to the elevated plasma Lp(a) levels of our centenarian population. We conclude therefore that high plasma Lp(a) levels are compatible with longevity.
流行病学研究表明，脂蛋白(a) [Lp(a)] 是心血管疾病的独立危险因素。Lp(a) 是一种富含胆固醇的、低密度脂蛋白 (LDL) 样颗粒，其上附着有一个大型糖蛋白，即载脂蛋白(a) [apo(a)]。血浆Lp(a) 水平在很大程度上由基因决定，受环境因素的影响较小。为了确定Lp(a) 是否可能与长寿相关，我们评估了一组法国百岁老人（n = 109）与对照组（n = 227）的Lp(a) 水平和apo(a) 异构体大小。百岁老人的平均年龄为101.5±2.4岁，而对照组为39.4±7.2岁。百岁老人和对照者的总胆固醇和甘油三酯血浆水平均在正常范围内。百岁老人（男性和女性）的Lp(a) 水平均高于血脂正常的对照组（平均Lp(a) 水平分别为0.33±0.42和0.22±0.27 mg/ml，P < 0.005）。与对照组相比，百岁老人群体中apo(a) 异构体的分布明显向较小的异构体大小偏移（分别为≤27个kringle [kr] 的异构体的54.4% 和41.4%，P = 0.04）。尽管如此，百岁老人中apo(a) 的大小分布并不能完全解释该群体中观察到的高Lp(a) 水平。除apo(a) 大小之外的其他因素，可能是遗传或环境性质的，似乎导致了我们百岁老人群体血浆Lp(a) 水平升高。因此，我们得出结论，高血浆Lp(a) 水平与长寿是相容的。
