Schechter M D
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272-0095, USA.
Eur J Pharmacol. 1998 Jan 12;341(2-3):131-4. doi: 10.1016/s0014-2999(97)01473-8.
The co-administration of D-lysergic acid diethylamide (LSD; 'Acid') and 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'; 'XTC'), has reached a prevalence that has allowed for the street terminology 'candyflipping' to describe the combination. Internet sites indicate a significant enhancement of central effects with their simultaneous use. In this preliminary observation, male Fawn-Hooded rats were trained to discriminate 1.5 mg/kg MDMA and were, subsequently, tested with doses of MDMA (0.15 mg/kg) or LSD (0.04 mg/kg) that each produced a saline-like response. Co-administration of these doses of MDMA and LSD synergized to produce a maximal MDMA-like response. The possible mechanism for synergistic action upon central serotonergic neurons is discussed to explain the observed effect.
麦角酸二乙酰胺（LSD；“迷幻药”）与3,4-亚甲基二氧甲基苯丙胺（MDMA；“摇头丸”；“XTC”）的联合使用已达到一定的流行程度，以至于出现了街头术语“糖果翻转”来描述这种组合。互联网网站显示，同时使用这两种药物会显著增强中枢效应。在这项初步观察中，对雄性小鹿斑鼠进行训练，使其能够辨别1.5毫克/千克的MDMA，随后用分别产生类似生理盐水反应的MDMA剂量（0.15毫克/千克）或LSD剂量（0.04毫克/千克）进行测试。这两种剂量的MDMA和LSD联合使用产生协同作用，产生最大的类似MDMA的反应。讨论了对中枢5-羟色胺能神经元协同作用的可能机制，以解释观察到的效应。
