Bekkelund S I, Aasebø U, Pierre-Jerome C, Holmboe J
Stakkevollan Occupational Health Centre, University Hospital, Tromsø, Norway.
Eur Respir J. 1998 Jan;11(1):194-7. doi: 10.1183/09031936.98.11010194.
The purpose of the study was to evaluate the accuracy of magnetic resonance imaging (MRI) in detecting subclinical morphological changes caused by asbestos exposure. Conventional chest radiographs according to the International Labour Organisation (ILO) categories 0-11 and spirometric data were compared with MRI in 17 men with mean (+/-2SD) asbestos exposure time of 24.6+/-13.0 yrs. Mean age was 62.0+/-9.4 yrs. The inclusion criterion was an ILO score of 2 or more. Electrocardiographic registrations and antirespiratory movement artefact techniques were used in all MRI examinations to avoid movement artefacts. Mean ILO grading was found to be 7.7+/-3.8 on chest radiography and 9.8+/-2.0 with MRI (p=0.01). Five patients had a higher ILO stage as evaluated by MRI, but in nine patients the staging remained unchanged. MRI revealed mediastinal adenopathy in four patients. Forced expiratory volume in one second (expressed as a percentage of the predicted value) was negatively correlated with ILO score as assessed by MRI (r=-0.4, p=0.032). Magnetic resonance imaging seems to be more sensitive than conventional radiographs in detecting subclinical fibrosis as well as the extent of pleural asbestosis.
本研究的目的是评估磁共振成像（MRI）检测石棉暴露所致亚临床形态学改变的准确性。将17名平均（±2标准差）石棉暴露时间为24.6±13.0年的男性患者的国际劳工组织（ILO）0 - 11类常规胸部X线片和肺功能数据与MRI结果进行比较。平均年龄为62.0±9.4岁。纳入标准为ILO评分2分或更高。所有MRI检查均采用心电图记录和抗呼吸运动伪影技术以避免运动伪影。胸部X线片的平均ILO分级为7.7±3.8，MRI为9.8±2.0（p = 0.01）。5例患者经MRI评估的ILO分期更高，但9例患者的分期未变。MRI显示4例患者有纵隔淋巴结肿大。一秒用力呼气量（以预测值的百分比表示）与MRI评估的ILO评分呈负相关（r = -0.4，p = 0.032）。磁共振成像在检测亚临床纤维化以及胸膜石棉沉着病的程度方面似乎比传统X线片更敏感。
