de Jong D, Kluin P M
Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis, afd. Pathologie, Amsterdam.
Ned Tijdschr Geneeskd. 1997 Aug 16;141(33):1601-13.
Non-Hodgkin lymphomas encompass a heterogeneous group of lymphoid malignancies from the clinical as well as from the pathological point of view. Consequently, one condition of optimal communication among pathologists, clinicians and scientific researchers is an adequate classification system. A new classification of lymphomas was proposed in September 1994, the Revised European-American Lymphoma Classification (REAL classification). The REAL classification is aiming at integration of pathological and clinical data, making it possible to distinguish clinical-pathological entities each of which has its characteristic pathological spectrum, clinical evolution and clinical presentation. The REAL classification is based not only on morphological and immunohistochemical but also on molecular and cytogenetic data. Such a system may make it possible to develop specific therapies for specific pathological entities. The REAL classification constitutes an important step forward in haemato-oncology.
从临床和病理角度来看，非霍奇金淋巴瘤包括一组异质性的淋巴系统恶性肿瘤。因此，病理学家、临床医生和科研人员之间实现最佳沟通的一个条件是有一个合适的分类系统。1994年9月提出了一种新的淋巴瘤分类方法，即修订的欧美淋巴瘤分类（REAL分类）。REAL分类旨在整合病理和临床数据，从而能够区分出具有各自特征性病理谱、临床演变过程和临床表现的临床病理实体。REAL分类不仅基于形态学和免疫组化数据，还基于分子和细胞遗传学数据。这样一个系统可能使针对特定病理实体开发特异性治疗方法成为可能。REAL分类是血液肿瘤学向前迈出的重要一步。
