Boks D E, Braat D D
Academisch Ziekenhuis Rotterdam-Dijkzigt, afd. Obstetrie en Gynaecologie.
Ned Tijdschr Geneeskd. 1997 Aug 23;141(34):1641-3.
Five women, aged 31, 26, 31, 34, and 28 years, became pregnant after oocyte donation and in-vitro fertilization. One was a carrier of Leber's optical atrophy, three had had an early menopause (in two because of chromosomal abnormalities), and one had had bilateral ovarian extirpation because of a cystadenoma and endometriosis. Three developed (pre-)eclampsia during pregnancy and one had a serious fluxus post partum. One twin died in utero, the other children were healthy. In the Netherlands in-vitro fertilization (with or without egg-donation) takes place up to the age of about 40. Regarding the high incidence of obstetrical complications in women under 40, raising the age limit could lead to even more pregnancy problems. Candidates for oocyte donation should be informed about these risks, furthermore they should not deliver at home.
五名年龄分别为31岁、26岁、31岁、34岁和28岁的女性在接受卵母细胞捐赠和体外受精后怀孕。其中一名是Leber视神经萎缩症携带者，三名经历过早绝经（两名是由于染色体异常），一名因囊腺瘤和子宫内膜异位症而进行了双侧卵巢切除。三名女性在怀孕期间发生了（先兆）子痫，一名在产后出现严重出血。一对双胞胎中的一个胎死腹中，其他孩子均健康。在荷兰，体外受精（无论是否有卵子捐赠）可进行至约40岁。鉴于40岁以下女性产科并发症的高发生率，提高年龄限制可能会导致更多的妊娠问题。卵母细胞捐赠的候选人应被告知这些风险，此外，她们不应在家分娩。
