Buescher U, Hertwig K, Wolf C, Dudenhausen J W
Department of Obstetrics, Rudolf Virchow University Hospital, Berlin, Germany.
Int J Gynaecol Obstet. 1998 Mar;60(3):257-63. doi: 10.1016/s0020-7292(98)00011-3.
To determinate the erythropoietin concentration in amniotic fluid in normal pregnancies and pregnancies with suspected hypoxia.
The erythropoietin concentration of 164 samples of amniotic fluid was determined by ELISA. The samples were taken by amniotomy during birth, as well as amniocentesis conducted during prenatal care.
A distribution of 1.07-7.29 U/l (10th-90th percentile) within the normal group (n = 106) was determined. Significantly elevated erythropoietin levels in amniotic fluid were determined in maternal hypertension (P = 0.039) and low birth-weight children (P = 0.0032). A correlation with the child's sex could be excluded.
Elevated erythropoietin levels in amniotic fluid indicated chronic fetal hypoxia.
测定正常妊娠及疑似缺氧妊娠孕妇羊水促红细胞生成素的浓度。
采用酶联免疫吸附测定法（ELISA）检测164份羊水样本的促红细胞生成素浓度。样本在分娩时通过羊膜穿刺术获取，以及在产前检查时进行羊膜腔穿刺获取。
正常组（n = 106）促红细胞生成素浓度分布为1.07 - 7.29 U/l（第10百分位数 - 第90百分位数）。在孕妇高血压（P = 0.039）和低体重儿（P = 0.0032）中，羊水促红细胞生成素水平显著升高。可排除与胎儿性别的相关性。
羊水中促红细胞生成素水平升高提示慢性胎儿缺氧。
