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异种移植有可能实现吗?

Will xenotransplantation ever be feasible?

作者信息

Starzl T E, Rao A S, Murase N, Fung J, Demetris A J

机构信息

Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA, USA.

出版信息

J Am Coll Surg. 1998 Apr;186(4):383-7. doi: 10.1016/s1072-7515(98)00053-2.

Abstract

In several recent conferences, the principal questions have been whether xenotransplantation technology should be encouraged and, if so, how it should be regulated. Because the prospect of successful transplantation of animal organs into humans is still remote, the rush to achieve consensus about clinical application would be inexplicable were it not for two ostensibly unrelated issues. The first is the small but undeniable theoretical hazard of causing new human infections with the intermingling of tissues from different species. The second, advanced by animal-rights advocates, concerns the spiritual and ethical relationship of humans to animals.

摘要

在最近的几次会议上,主要问题一直是是否应该鼓励异种移植技术,如果是,又该如何对其进行监管。由于将动物器官成功移植到人类体内的前景仍然遥远,若不是存在两个表面上不相关的问题,急于就临床应用达成共识将是难以解释的。第一个问题是,不同物种组织的混合会带来新的人类感染,虽然风险很小但不可否认。第二个问题是动物权利倡导者提出的,涉及人类与动物的精神和伦理关系。

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本文引用的文献

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RENAL HETEROTRANSPLANTATION IN MAN.人类肾异体移植
Ann Surg. 1964 Sep;160(3):384-410. doi: 10.1097/00000658-196409000-00006.
7
The lost chord: microchimerism and allograft survival.失落的和弦:微嵌合体与同种异体移植存活
Immunol Today. 1996 Dec;17(12):577-84; discussion 588. doi: 10.1016/s0167-5699(96)10070-0.
8
Xenotransplantation: recent progress and current perspectives.异种移植:近期进展与当前展望
Curr Opin Immunol. 1996 Oct;8(5):721-8. doi: 10.1016/s0952-7915(96)80091-4.
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Delayed xenograft rejection.延迟性异种移植排斥反应。
Immunol Today. 1996 Aug;17(8):379-84. doi: 10.1016/0167-5699(96)10024-4.

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