Fall C H, Stein C E, Kumaran K, Cox V, Osmond C, Barker D J, Hales C N
MRC Environmental Epidemiology Unit, Southampton General Hospital, UK.
Diabet Med. 1998 Mar;15(3):220-7. doi: 10.1002/(SICI)1096-9136(199803)15:3<220::AID-DIA544>3.0.CO;2-O.
Recent research in Europe and the USA has shown that adults who had a low birthweight or who were thin at birth with a low ponderal index (birthweight/length3) tend to be insulin resistant and have an increased risk of developing Type 2 diabetes mellitus. Low birthweight and Type 2 diabetes are common in India. We have studied glucose and insulin metabolism in 506 men and women (aged 39-60 years) born in a hospital in Mysore, South India, which kept detailed obstetric records from 1934. The prevalence of Type 2 diabetes was 15%. In contrast to Western populations, higher rates were found in men and women who were short at birth (p = 0.07) and had a high ponderal index (p = 0.05). Their mothers tended to be heavier than average during pregnancy (p = 0.004). Higher ponderal index at birth was also associated with a lower 30 minute insulin increment (p = 0.009), a marker of reduced beta cell function. We speculate that the rise in Type 2 diabetes in Indian urban populations may have been triggered by mild obesity in mothers, leading to glucose intolerance during pregnancy, macrosomic changes in the fetus, and insulin deficiency in adult life.
欧洲和美国最近的研究表明，出生体重低或出生时体重轻且 ponderal 指数（出生体重/身长³）低的成年人往往存在胰岛素抵抗，患 2 型糖尿病的风险增加。低出生体重和 2 型糖尿病在印度很常见。我们对 506 名在印度南部迈索尔一家医院出生的男性和女性（年龄在 39 - 60 岁之间）的葡萄糖和胰岛素代谢进行了研究，该医院保存了 1934 年以来的详细产科记录。2 型糖尿病的患病率为 15%。与西方人群不同的是，出生时身材矮小（p = 0.07）且 ponderal 指数高（p = 0.
