Balaban N, Goldkorn T, Nhan R T, Dang L B, Scott S, Ridgley R M, Rasooly A, Wright S C, Larrick J W, Rasooly R, Carlson J R
Department of Medical Pathology, University of California, Davis, CA 95616, USA.
Science. 1998 Apr 17;280(5362):438-40. doi: 10.1126/science.280.5362.438.
Staphylococcus aureus causes pathologies ranging from minor skin infections to life-threatening diseases. Pathogenic effects are largely due to production of bacterial toxin, which is regulated by an RNA molecule, RNAIII. The S. aureus protein called RAP (RNAIII activating protein) activates RNAIII, and a peptide called RIP (RNAIII inhibiting peptide), produced by a nonpathogenic bacteria, inhibits RNAIII. Mice vaccinated with RAP or treated with purified or synthetic RIP were protected from S. aureus pathology. Thus, these two molecules may provide useful approaches for the prevention and treatment of diseases caused by S. aureus.
金黄色葡萄球菌可引发从轻微皮肤感染到危及生命的疾病等一系列病理状况。致病作用很大程度上归因于细菌毒素的产生，而细菌毒素由一种RNA分子RNAIII调控。金黄色葡萄球菌中一种名为RAP（RNAIII激活蛋白）的蛋白质可激活RNAIII，一种由非致病性细菌产生的名为RIP（RNAIII抑制肽）的肽可抑制RNAIII。用RAP接种疫苗或用纯化的或合成的RIP进行治疗的小鼠可免受金黄色葡萄球菌致病作用的影响。因此，这两种分子可能为预防和治疗由金黄色葡萄球菌引起的疾病提供有用的方法。
