Kishida T, Tamaki Y
Department of Forensic Medicine, Oita Medical University, Japan.
Nihon Hoigaku Zasshi. 1997 Dec;51(6):430-2.
In a deficiency case of maternity dispute where the father and his two wives were dead and only the six children were available for testing, we analyzed three sex-linked short tandem repeat (STR) loci DYS19, HPRT, and AR. On the basis of the typing results of the HPRT and AR loci, we obtained probabilities of maternity ranging from 0.9256 to 0.9724 for five of the six children. The results supported those of typing for 24 conventional hemogenetic markers and 11 autosomal STRs, enabling us to establish maternity. The present study demonstrates the utility of sex-chromosomal STR typing in the solution of deficiency cases of disputed parentage.
在一个父亲及其两任妻子均已死亡、仅有六个孩子可供检测的母系争议缺失案例中，我们分析了三个性连锁短串联重复序列（STR）基因座DYS19、次黄嘌呤磷酸核糖转移酶（HPRT）和雄激素受体（AR）。根据HPRT和AR基因座的分型结果，我们得出六个孩子中五个孩子的母系概率在0.9256至0.9724之间。这些结果支持了24个常规血液遗传标记和11个常染色体STR分型的结果，使我们能够确定母系关系。本研究证明了性染色体STR分型在解决亲子关系争议缺失案例中的实用性。
