血清白细胞介素-6作为慢性根尖周病变的血清学标志物：一项病例对照研究。
Serum Interleukin-6 as a Serologic Marker of Chronic Periapical Lesions: A Case-control Study.
作者信息
Abdolsamadi Hamid Reza, Vahedi Mohammad, Esmaeili Farzad, Nazari Shahrzad, Abdollahzadeh Shermin
机构信息
Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Hamadan University of Medical Sciences, Iran.
出版信息
J Dent Res Dent Clin Dent Prospects. 2008 Spring;2(2):43-7. doi: 10.5681/joddd.2008.009. Epub 2008 Aug 15.
BACKGROUND AND AIMS
Chronic periapical disease with pulpal origin is an inflammatory condition caused by bacterial infection. Chronic infection could affect general health by increasing the production of cytokines such as interleukin-6 (IL-6) that probably play a role in pathogenesis of pulpal and periapical diseases. The aim of the present study was a comparative evaluation of the level of serum IL 6 in patients with periapical lesions and healthy controls.
MATERIALS AND METHODS
This analytical case-control study included 40 patients with chronic peri-apical lesions and 40 individuals without any oral diseases. All of the participants were in good general health. After obtaining an informed consent, clinical and radiographic examinations were carried out and blood samples were collected. Serum IL-6 was measured using ELISA. Data were analyzed using t-test by SPSS 14.0 computer software.
RESULTS
Serum IL-6 concentration was significantly higher in test group compared to the controls (P < 0.05).
CONCLUSION
The results of the present study indicate that IL-6 produced in periapical lesions may serve as a marker of pathologic inflammatory activities in chronic periapical lesions.
背景与目的
源自牙髓的慢性根尖周病是一种由细菌感染引起的炎症状态。慢性感染可能通过增加细胞因子如白细胞介素-6（IL-6）的产生来影响全身健康，IL-6可能在牙髓病和根尖周病的发病机制中起作用。本研究的目的是对根尖周病变患者和健康对照者血清IL-6水平进行比较评估。
材料与方法
这项分析性病例对照研究纳入了40例慢性根尖周病变患者和40例无任何口腔疾病的个体。所有参与者全身健康状况良好。在获得知情同意后，进行了临床和影像学检查并采集了血样。使用酶联免疫吸附测定法（ELISA）检测血清IL-6。数据采用SPSS 14.0计算机软件进行t检验分析。
结果
与对照组相比，试验组血清IL-6浓度显著更高（P < 0.05）。
结论
本研究结果表明，根尖周病变中产生的IL-6可能作为慢性根尖周病变病理性炎症活动的标志物。
Zotero 插件