Cheynier R, Gratton S, Halloran M, Stahmer I, Letvin N L, Wain-Hobson S
Unité de Rétrovirologie Moléculaire, Institut Pasteur, Paris.
Nat Med. 1998 Apr;4(4):421-7. doi: 10.1038/nm0498-421.
The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCG inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV variant was noted, probably as a result of the infiltration of activated antigen-specific T cell clones as opposed to infection by blood borne virus in situ. The dynamics of SIV quasispecies in peripheral blood suggests sequential waves of viral replication, illustrating the role of antigenic stimulation as a driving force in viral dissemination and pathogenesis.
在对一只感染了猿猴免疫缺陷病毒（SIV）的猕猴进行反复静脉注射卡介苗后，研究了抗原刺激对SIV复制动力学的影响。在对结核分枝杆菌纯化蛋白衍生物的迟发型超敏反应部位，发现了一种独特的SIV变体，这可能是由于活化的抗原特异性T细胞克隆浸润所致，而非原位血源病毒感染。外周血中SIV准种的动力学表明病毒复制呈连续波状，说明了抗原刺激在病毒传播和发病机制中作为驱动力的作用。
