Boutros N N, Bowers M B, Quinlan D
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
J Neuropsychiatry Clin Neurosci. 1998 Winter;10(1):48-54. doi: 10.1176/jnp.10.1.48.
Disagreement remains as to whether drug use can result in an autonomous psychotic disorder. If drug use can create new psychosis cases, an increase in the number of psychosis patients ought to be observable following periods of increased drug use by the general population. First admissions data for the categories of drug abuse and schizophrenia/paranoid disorders from all Connecticut state hospitals from 1965 to 1983 were examined to determine the prevalence of psychotic disorders before, during, and after a period of increased drug use by the general population. Affective disorders first admissions were examined for comparison. A rapid increase in new schizophrenia admissions coincided with a peak period for drug-related admissions. The data suggest that increased drug use of the late 1960s may have contributed to the increase noted 3 to 5 years later in first admissions of patients diagnosed with psychotic disorders.
关于药物使用是否会导致自主性精神障碍，目前仍存在分歧。如果药物使用会引发新的精神病病例，那么在普通人群药物使用增加一段时间后，应该可以观察到精神病患者数量的增加。对1965年至1983年康涅狄格州所有州立医院的药物滥用和精神分裂症/偏执性障碍类别的首次入院数据进行了检查，以确定在普通人群药物使用增加之前、期间和之后精神障碍的患病率。为作比较，还检查了情感障碍的首次入院情况。新的精神分裂症入院人数的快速增加与药物相关入院的高峰期相吻合。数据表明，20世纪60年代末药物使用的增加可能导致了3至5年后被诊断为精神障碍患者首次入院人数的增加。
