心率变异性作为酒精成瘾者线索反应性的指标。
Heart rate variability as an index of cue reactivity in alcoholics.
作者信息
Rajan I, Murthy P J, Ramakrishnan A G, Gangadhar B N, Janakiramaiah N
机构信息
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
出版信息
Biol Psychiatry. 1998 Apr 1;43(7):544-6. doi: 10.1016/s0006-3223(97)00399-5.
BACKGROUND
Autonomic responses follow exposure to conditioned stimuli such as contextual factors associated with alcohol ingestion. Heart rate variability is under autonomic control and may be a measure of such response.
METHODS
Twenty alcoholics and 23 matched social drinkers (all male) were exposed to a neutral cue and then an alcohol cue in identical settings, during which the electrocardiogram of these subjects was recorded. Time and frequency domain parameters of heart rate variability (HRV) were computed by a blind rater.
RESULTS
Coefficient of variation of R-R intervals and absolute powers of HRV spectrum (in frequency bands 0.05-0.15 Hz and 0.01-0.05 Hz) following alcohol cue were significantly higher in alcoholics than social drinkers. The mean heart rate (MHR) failed to reflect this difference.
CONCLUSIONS
HRV paradigm appears more sensitive than MHR to measure cue reactivity.
背景
自主反应在接触条件刺激（如与酒精摄入相关的情境因素）后会出现。心率变异性受自主神经系统控制，可能是这种反应的一种度量指标。
方法
20名酗酒者和23名匹配的社交饮酒者（均为男性）在相同环境中先接触中性线索，然后接触酒精线索，在此期间记录这些受试者的心电图。心率变异性（HRV）的时域和频域参数由一名不知情的评估者计算得出。
结果
酗酒者在接触酒精线索后的R-R间期变异系数和HRV频谱的绝对功率（在0.05 - 0.15赫兹和0.01 - 0.05赫兹频段）显著高于社交饮酒者。平均心率（MHR）未能反映出这种差异。
结论
HRV范式在测量线索反应性方面似乎比MHR更敏感。
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