Jokimaa V, Inki P, Kujari H, Hirvonen O, Ekholm E, Anttila L
Department of Obstetrics and Gynaecology, University of Turku, Finland.
Placenta. 1998 Mar-Apr;19(2-3):157-63. doi: 10.1016/s0143-4004(98)90004-2.
Syndecan-1 is a cell surface heparan sulphate proteoglycan, which binds to the extracellular matrix (ECM), growth factors and antithrombin III. The early expression of syndecan-1 during mouse embryonic development suggests a potential role in the communication between the embryo and the ECM of decidua. Using immunohistochemical methods, the present study showed that the expression of syndecan-1 in the trophoblast cells changes along trophoblast differentiation. The syncytiotrophoblasts in the chorionic villi exhibited an apical expression of syndecan-1. This suggests that the expression is restricted to non-migrating, non-proliferating trophoblasts. The mode of syndecan-1 expression by human placental trophoblasts is independent of gestational age. The expression is not changed in miscarriages. In pre-eclampsia, the staining for syndecan-1 on the villous syncytiotrophoblast is weaker compared to normal pregnancy, but in placental bed the expression is similar. The unique apical localization of syndecan-1 in chorionic villi, not detected in any other tissues, suggests a potential role in fetomaternal communication probably via growth factor binding and in anticoagulation of intervillous circulation.
Syndecan-1是一种细胞表面硫酸乙酰肝素蛋白聚糖，它可与细胞外基质（ECM）、生长因子及抗凝血酶III结合。Syndecan-1在小鼠胚胎发育过程中的早期表达提示其在胚胎与蜕膜ECM之间的通讯中可能发挥作用。本研究采用免疫组化方法显示，滋养层细胞中Syndecan-1的表达随滋养层分化而变化。绒毛膜绒毛中的合体滋养层细胞呈现Syndecan-1的顶端表达。这表明该表达局限于非迁移、非增殖的滋养层细胞。人胎盘滋养层细胞中Syndecan-1的表达模式与孕周无关。流产时其表达无变化。在子痫前期，与正常妊娠相比，绒毛合体滋养层上Syndecan-1的染色较弱，但在胎盘床其表达相似。Syndecan-1在绒毛膜绒毛中独特的顶端定位在其他任何组织中均未检测到，提示其可能通过生长因子结合在母胎通讯以及绒毛间隙循环抗凝中发挥作用。
