Sámal M, Bergmann H
Department of Nuclear Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Nucl Med Commun. 1998 Feb;19(2):161-71.
A hybrid phantom is a synthetic dynamic scintigraphic study reconstructed from dynamic components of real clinical data. The aim of a hybrid simulation is to provide realistic reference studies with systematically varying quantitative diagnostic parameters for testing the quality of measurement of regional dynamics. The components of the phantom are extracted from a representative patient study using factor analysis. Prior to the construction of the phantom, selected components are modified in a known way or substituted with heterologous data. The phantom study is constituted from the altered components using a procedure inverse to factor analysis, and completed by the addition of residual noise. The hybrid phantom is a compromise between simulated and software phantoms. Unlike simulated phantoms, it preserves a significant part of data variability and the natural complex structure of scintigraphic images. Unlike software phantoms, it provides values for selected diagnostic parameters or magnitudes of their relative changes. A set of hybrid phantoms from a dynamic renal study and the results of a pilot clinical evaluation are presented.
混合体模是一种从真实临床数据的动态成分重建而来的合成动态闪烁扫描研究。混合模拟的目的是提供具有系统变化的定量诊断参数的逼真参考研究，以测试区域动力学测量的质量。体模的成分通过因子分析从代表性患者研究中提取。在构建体模之前，选定的成分以已知方式进行修改或用异源数据替代。体模研究由使用与因子分析相反的程序从改变后的成分构成，并通过添加残余噪声来完成。混合体模是模拟体模和软件体模之间的一种折衷。与模拟体模不同，它保留了数据变异性的很大一部分以及闪烁扫描图像的自然复杂结构。与软件体模不同，它提供选定诊断参数的值或其相对变化的幅度。本文展示了一组来自动态肾脏研究的混合体模以及初步临床评估的结果。
