Karagöz I, Eroğul O
Biomedical and Clinical Engineering Centre, Gülhane Military Medical Academy, Ankara, Turkey.
Med Eng Phys. 1998 Sep;20(6):473-9. doi: 10.1016/s1350-4533(98)00028-9.
Various phantoms have been proposed in order to simulate the physical structures of human organs, such as those used in computerized brain tomography. Studying the functional behaviour of kidney by means of functional imaging techniques suffers from a lack of dynamic renal phantom for simulation. In this study a new dynamic renal phantom (DRP) is proposed and the first test results are reported which demonstrate the significance of deconvolution analysis in scintigraphy. The main idea in the construction of our DRP involves the filtration of chemical substances from the blood by flowing it through coiled tubes surrounded by semipermeable membranes. The DRP tests are performed with Technetium-99m (Tc-99m). The semipermeable membrane in the DRP passes Tc-99m, salts and small molecules but not blood cells and large protein molecules. The proposed DRP is tested using pixel basis renal functional radionuclide imaging techniques and promising results are obtained.
为了模拟人体器官的物理结构，人们提出了各种体模，比如计算机化脑断层扫描中使用的那些。利用功能成像技术研究肾脏的功能行为存在缺乏用于模拟的动态肾脏体模的问题。在本研究中，提出了一种新的动态肾脏体模（DRP），并报告了首次测试结果，这些结果证明了反卷积分析在闪烁扫描术中的重要性。构建我们的DRP的主要思路是让血液流经被半透膜包围的盘管，从而从血液中过滤化学物质。DRP测试使用锝-99m（Tc-99m）进行。DRP中的半透膜能让Tc-99m、盐和小分子通过，但不让血细胞和大蛋白质分子通过。使用基于像素的肾脏功能放射性核素成像技术对所提出的DRP进行了测试，并获得了有前景的结果。
