Bars D, Menetrey D, Conseiller C, Besson J M
Eur J Pharmacol. 1976 Jul;38(1):165-73. doi: 10.1016/0014-2999(76)90213-2.
The effects of steroid anaesthesia (Althesin -CT 1341) on dorsal horn cells (laminae 4 and 5) were studied by extracellular recordings in the spinal cat. I.v. administration of Althesin (0.2 ml/kg) strongly depressed the spontaneous and evoked activities of both types of cells. No differences were found between cells activated by noxious or innocuous stimuli. These results emphasize the fact that the transmission of afferent messages is depressed by various anaesthetics at the level of the first synapses in the CNS. The depressive effects on lamina 5 cells could explain in part the analgesic effects of Althesin.
通过对脊髓猫进行细胞外记录，研究了类固醇麻醉剂（阿法沙龙-CT 1341）对背角细胞（第4和5层）的影响。静脉注射阿法沙龙（0.2毫升/千克）可强烈抑制这两种类型细胞的自发活动和诱发活动。在由有害或无害刺激激活的细胞之间未发现差异。这些结果强调了这样一个事实，即在中枢神经系统的第一个突触水平，各种麻醉剂会抑制传入信息的传递。对第5层细胞的抑制作用可能部分解释了阿法沙龙的镇痛作用。
