阿法沙龙和氯胺酮对大鼠静息及应激刺激下肾上腺皮质活动的影响。

Effects of althesin and ketamine on resting and stress stimulated adrenocortical activity in rats.

作者信息

Nisticò G, Pisanti N, Rotiroti D, Preziosi P, Cuocolo R, de Martino G, Nisticò G M

出版信息

Br J Anaesth. 1978 Sep;50(9):891-7. doi: 10.1093/bja/50.9.891.

DOI:10.1093/bja/50.9.891

Abstract

The effects were studied of two i.v. anaesthetics (Althesin and ketamine) on resting and activated adrenocortical function in the rat. Small doses of Althesin and ketamine comparable to those required to produce induction of anaesthesia in man evoked adrenocortical stimulation, but the stressing effects of ketamine were more prolonged. During deep anaesthesia with either anaesthetic there was an inhibition of pituitary adrenal activation induced by handling and surgery. However, during recovery, ketamine was associated with intense and prolonged adrenocortical stimulation. The stress of laparotomy in control rats and in rats pretreated with the anaesthetics caused a depletion of noradrenaline in the hypothalamus; this suggests that both anaesthetics inhibit adrenocortical activation by mechanisms different from adrenergic inhibition.

摘要

研究了两种静脉麻醉剂（阿法沙龙和氯胺酮）对大鼠静息和激活状态下肾上腺皮质功能的影响。与人体麻醉诱导所需剂量相当的小剂量阿法沙龙和氯胺酮可引起肾上腺皮质刺激，但氯胺酮的应激效应持续时间更长。使用任何一种麻醉剂进行深度麻醉时，由处理和手术引起的垂体 - 肾上腺激活均受到抑制。然而，在恢复过程中，氯胺酮会导致强烈且持续时间长的肾上腺皮质刺激。对照大鼠和用麻醉剂预处理的大鼠开腹手术的应激导致下丘脑去甲肾上腺素耗竭；这表明两种麻醉剂通过不同于肾上腺素能抑制的机制抑制肾上腺皮质激活。