Sakurai Y, Klein S
Department of Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Surg Today. 1998;28(3):247-57. doi: 10.1007/s005950050116.
During the past 20 years, efforts have been made to elucidate the metabolic changes observed in patients with cancer by using stable and radioactive isotopic tracers. These metabolic changes in patients with cancer may be similar to those in other stress conditions, in which glucose production and utilization, lipolysis and free fatty acid flux, and net protein catabolism are increased. Stress hormones, such as glucagon and catecholamines, and certain cytokines may be responsible for these metabolic changes. Although it has been shown that cachexia in patients with cancer signals a poor prognosis, efforts to improve the clinical outcomes with nutritional support have been disappointing. The failure of cancer patients to respond to nutritional support may be related to an alteration in the intermediate metabolism. Therefore, further research evaluating the metabolic abnormalities associated with cancer may lead to more effective nutritional therapies.
在过去20年中，人们致力于通过使用稳定和放射性同位素示踪剂来阐明癌症患者所观察到的代谢变化。癌症患者的这些代谢变化可能与其他应激状态下的变化相似，在其他应激状态下，葡萄糖生成与利用、脂肪分解和游离脂肪酸通量以及净蛋白分解代谢都会增加。应激激素，如胰高血糖素和儿茶酚胺，以及某些细胞因子可能是这些代谢变化的原因。尽管已经表明癌症患者的恶病质预示着预后不良，但通过营养支持改善临床结局的努力却令人失望。癌症患者对营养支持无反应可能与中间代谢的改变有关。因此，进一步研究评估与癌症相关的代谢异常可能会带来更有效的营养治疗方法。
