Klein S, Koretz R L
Nutr Clin Pract. 1994 Jun;9(3):91-100. doi: 10.1177/011542659400900391.
Although more than 70 prospective randomized controlled trials have evaluated the use of nutrition support in patients with cancer, the indications for nutrition therapy in this patient population remain controversial. We reviewed the published prospective randomized controlled trials that evaluated clinically important endpoints (morbidity, mortality, and duration of hospitalization). Many trials had serious shortcomings in study design that limit the ability to draw definitive conclusions from the data. In general, the data failed to demonstrate the clinical efficacy of providing nutrition support to most patients with cancer. Therefore, the indications for using nutrition therapy should be the same as those for patients with benign disease.
尽管已有70多项前瞻性随机对照试验评估了营养支持在癌症患者中的应用，但该患者群体营养治疗的指征仍存在争议。我们回顾了已发表的评估临床重要终点（发病率、死亡率和住院时间）的前瞻性随机对照试验。许多试验在研究设计上存在严重缺陷，限制了从数据中得出明确结论的能力。总体而言，数据未能证明对大多数癌症患者提供营养支持的临床疗效。因此，使用营养治疗的指征应与良性疾病患者相同。
