Kitagawa T, Matsumoto K, Iriyama K
Second Department of Surgery, Mie University School of Medicine, Edobashi, Tsu, Japan.
Surg Today. 1998;28(3):262-7. doi: 10.1007/s005950050118.
The serum levels of intercellular adhesion molecule-1 (sICAM-1) and endothelial leukocyte adhesion molecule-1 (sELAM-1) were determined in 40 patients with colorectal cancer. The sICAM-1 and sELAM-1 levels in the drainage venous blood adjacent to a tumor were significantly correlated with those in the peripheral venous blood in patients without evident hematogenous dissemination of tumor cells. The sICAM-1 levels in peripheral venous blood were significantly higher in patients with hepatic metastases, while the sELAM-1 levels were significantly higher in those with pulmonary metastases. An immunohistochemical study of metastatic sites in the liver revealed that ICAM-1 was expressed in cancer stroma, but not in the cancer cells. In conclusion, the sICAM-1 and sELAM-1 levels in the peripheral venous blood in colorectal cancer patients without any distant metastasis are likely to reflect the topical production of these cell adhesion molecules, and appear to be instructive in predicting hematogenous dissemination in patients with colorectal cancer.
对40例结直肠癌患者测定了细胞间黏附分子-1（sICAM-1）和内皮白细胞黏附分子-1（sELAM-1）的血清水平。在无明显肿瘤细胞血行播散的患者中，肿瘤旁引流静脉血中的sICAM-1和sELAM-1水平与外周静脉血中的水平显著相关。肝转移患者外周静脉血中的sICAM-1水平显著升高，而肺转移患者的sELAM-1水平显著升高。对肝脏转移部位的免疫组织化学研究显示，ICAM-1在癌基质中表达，但在癌细胞中不表达。总之，无远处转移的结直肠癌患者外周静脉血中的sICAM-1和sELAM-1水平可能反映这些细胞黏附分子的局部产生，并且似乎对预测结直肠癌患者的血行播散具有指导意义。
