Hanson L A, Gorzalka B B, Brotto L A
Department of Psychology, The University of British Columbia, Vancouver, Canada.
Eur J Pharmacol. 1998 Jan 26;342(2-3):163-5. doi: 10.1016/s0014-2999(97)01574-4.
The effects of chronic corticosterone administration on sexual behavior and on wet-dog shakes, a 5-HT2A mediated behavior, were investigated in the female rat. In addition, effects of the antidepressant nefazodone, a selective 5-HT2A receptor antagonist, both alone and in combination with corticosterone were examined. Testing was conducted in ovariectomized animals primed with estrogen and progesterone. Corticosterone was found to significantly increase sexual receptivity, sexual proceptivity and wet dog shakes. While nefazodone alone had no significant effects, it completely attenuated the corticosterone-induced increases in both sexual behavior and wet dog shakes. This suggests that corticosterone influences sexual behavior and wet dog shakes via a 5-HT2A receptor mechanism.
在雌性大鼠中研究了长期给予皮质酮对性行为以及对湿狗摇（一种5-HT2A介导的行为）的影响。此外，还研究了抗抑郁药奈法唑酮（一种选择性5-HT2A受体拮抗剂）单独使用以及与皮质酮联合使用的效果。测试在经雌激素和孕酮预处理的去卵巢动物中进行。发现皮质酮显著增加性接受度、性主动行为和湿狗摇。虽然单独使用奈法唑酮没有显著影响，但它完全减弱了皮质酮诱导的性行为和湿狗摇的增加。这表明皮质酮通过5-HT2A受体机制影响性行为和湿狗摇。
