Matsuda J, Suzuki M, Nozaki C, Shinya N, Tashiro K, Mizuno K, Uchinuno Y, Yamamura K
The Chemo-Sero-Therapeutic Research Institute, Kikuchi Research Center, Pathology Department, Kumamoto.
Jpn J Cancer Res. 1998 Feb;89(2):150-8. doi: 10.1111/j.1349-7006.1998.tb00543.x.
Hepatitis C virus (HCV), a major causative agent of post transfusion non-A, non-B hepatitis (NANBH), can only infect humans and chimpanzees. We produced nine transgenic mouse lines carrying a full-length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver-specific expression. In one of these lines HCV mRNA and HCV core protein were detected in the liver of the transgenic mouse, although the levels of expression were very low. In addition, HCV-related antibody was detected in the serum.
丙型肝炎病毒（HCV）是输血后非甲非乙型肝炎（NANBH）的主要致病因子，仅感染人类和黑猩猩。我们构建了九条携带全长HCV cDNA并由人血清淀粉样蛋白P成分（hSAP）启动子驱动的转基因小鼠品系，该启动子可指导肝脏特异性表达。在其中一个品系的转基因小鼠肝脏中检测到了HCV mRNA和HCV核心蛋白，尽管表达水平很低。此外，在血清中检测到了HCV相关抗体。
