幽门螺杆菌感染的十二指肠溃疡和非溃疡性消化不良患者的抗胃自身抗体与胃分泌功能
Antigastric autoantibodies and gastric secretory function in Helicobacter pylori-infected patients with duodenal ulcer and non-ulcer dyspepsia.
作者信息
Faller G, Winter M, Steininger H, Konturek P, Konturek S J, Kirchner T
机构信息
Institute of Pathology and Dept. of Internal Medicine I, University of Erlangen-Nürnberg, Erlangen, Germany.
出版信息
Scand J Gastroenterol. 1998 Mar;33(3):276-82. doi: 10.1080/00365529850170865.
BACKGROUND
Autoantibodies against epitopes located at the canaliculi of human parietal cells occur in about 30% of Helicobacter pylori-infected patients. This has led to the hypothesis that gastric secretory function could be inhibited by anticanalicular autoantibodies in H. pylori gastritis.
METHODS
Forty-four H. pylori-infected patients with and without duodenal ulcers were screened for anticanalicular autoantibodies by means of immunohistochemistry. Plasma gastrin levels and basal and maximal gastric acid output were determined.
RESULTS
Fasting gastrin levels were significantly increased in the group with anticanalicular autoantibodies. In the group of patients with non-ulcer dyspepsia the presence of anticanalicular autoantibodies was significantly correlated with an impaired basal acid secretion.
CONCLUSIONS
Antigastric autoimmunity in H. pylori gastritis seems to be relevant for gastric hyposecretion either directly by inhibiting the proton pump or indirectly through the development of gastric mucosa atrophy.
背景
在大约30%的幽门螺杆菌感染患者中会出现针对人壁细胞小管处表位的自身抗体。这引发了一种假说，即在幽门螺杆菌胃炎中，抗小管自身抗体可能会抑制胃分泌功能。
方法
通过免疫组织化学对44例幽门螺杆菌感染且有或无十二指肠溃疡的患者进行抗小管自身抗体筛查。测定血浆胃泌素水平以及基础胃酸分泌量和最大胃酸分泌量。
结果
有抗小管自身抗体的组中空腹胃泌素水平显著升高。在非溃疡性消化不良患者组中，抗小管自身抗体的存在与基础胃酸分泌受损显著相关。
结论
幽门螺杆菌胃炎中的抗胃自身免疫似乎与胃分泌减少有关，其机制可能是直接抑制质子泵，或者通过胃黏膜萎缩的发展间接导致。
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