两种植物蜕皮甾类化合物杰拉地甾酮和22-表-20-羟基蜕皮酮的分离与结构解析

Isolation and Structural Elucidation of Two Plant Ecdysteroids, Gerardiasterone and 22-Epi-20-hydroxyecdysone.

作者信息

Bathori M, Mathe I, Girault J, Kalasz H, Lafont R

机构信息

Albert Szent-Gyorgyi Medical University, Department of Pharmacognosy, P.O. Box 121, H-6701 Szeged, Hungary, Université Rene Descartes, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS URA 400, 45 rue des Saints-Peres, F-75006 Paris, France, Semmelweis University of Medicine, Department of Pharmacology, P.O. Box 370, H-1445 Budapest, Hungary, and Ecole Normale Superieure, Département de Biologie, Laboratoire de Biochimie, CNRS EP 119, 46 rue d'Ulm, F-75230 Paris Cedex 05, France.

出版信息

J Nat Prod. 1998 Mar 27;61(3):415-7. doi: 10.1021/np970124y.

DOI:10.1021/np970124y

PMID:9548888

Abstract

Two minor plant ecdysteroids, 22-epi-20-hydroxyecdysone (1) and gerardiasterone (2), were isolated from Serratula tinctoria L. (Compositae). The first compound, a new natural product, was characterized by an unusual stereochemistry at C-22 (i.e., 22S). The second compound was identified as (20R,23S)-20,23-dihydroxyecdysone, a compound previously isolated from the Zooanthid Gerardia savaglia.

摘要

从染用麻花头（菊科）中分离出两种次要的植物蜕皮甾体，22-表-20-羟基蜕皮酮（1）和gerardiasterone（2）。第一种化合物是一种新的天然产物，其特征在于C-22位具有不寻常的立体化学结构（即22S）。第二种化合物被鉴定为（20R，23S）-20,23-二羟基蜕皮酮，该化合物先前已从珊瑚虫Gerardia savaglia中分离得到。