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Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant.将PR基因表达与NPR1及细菌抗性解偶联：拟南芥显性突变体cpr6-1的特性分析
Plant Cell. 1998 Apr;10(4):557-69. doi: 10.1105/tpc.10.4.557.
2
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3
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Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance.snc1突变体中EDS1介导的R基因途径的激活导致组成型、不依赖NPR1的病原体抗性。
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本文引用的文献

1
A central role of salicylic Acid in plant disease resistance.水杨酸在植物抗病性中的核心作用。
Science. 1994 Nov 18;266(5188):1247-50. doi: 10.1126/science.266.5188.1247.
2
Requirement of salicylic Acid for the induction of systemic acquired resistance.水杨酸诱导系统获得性抗性的要求。
Science. 1993 Aug 6;261(5122):754-6. doi: 10.1126/science.261.5122.754.
3
Increase in salicylic Acid at the onset of systemic acquired resistance in cucumber.黄瓜系统获得性抗性起始阶段水杨酸的增加。
Science. 1990 Nov 16;250(4983):1004-6. doi: 10.1126/science.250.4983.1004.
4
Salicylic Acid: a likely endogenous signal in the resistance response of tobacco to viral infection.水杨酸：烟草抗病毒感染抗性反应中的一种可能的内源性信号。
Science. 1990 Nov 16;250(4983):1002-4. doi: 10.1126/science.250.4983.1002.
5
Systemic Induction of Salicylic Acid Accumulation in Cucumber after Inoculation with Pseudomonas syringae pv syringae.接种丁香假单胞菌 pv 丁香后黄瓜中水杨酸积累的系统性诱导。
Plant Physiol. 1991 Dec;97(4):1342-7. doi: 10.1104/pp.97.4.1342.
6
Biological function of ;pathogenesis-related' proteins: four PR proteins of tobacco have 1,3-beta-glucanase activity."pathogenesis-related" 蛋白的生物学功能：烟草中的 4 种 PR 蛋白具有 1,3-β-葡聚糖酶活性。
EMBO J. 1987 Nov;6(11):3209-12. doi: 10.1002/j.1460-2075.1987.tb02637.x.
7
Systemic acquired resistance induced by localized virus infections in plants.植物局部病毒感染诱导的系统获得性抗性。
Virology. 1961 Jul;14:340-58. doi: 10.1016/0042-6822(61)90319-1.
8
Coordinate Gene Activity in Response to Agents That Induce Systemic Acquired Resistance.响应诱导系统获得性抗性的因子协调基因活性
Plant Cell. 1991 Oct;3(10):1085-1094. doi: 10.1105/tpc.3.10.1085.
9
Temperature-Dependent Induction of Salicylic Acid and Its Conjugates during the Resistance Response to Tobacco Mosaic Virus Infection.烟草花叶病毒感染抗性反应过程中水杨酸及其共轭物的温度依赖性诱导
Plant Cell. 1992 Mar;4(3):359-366. doi: 10.1105/tpc.4.3.359.
10
Characterization of an Arabidopsis Mutant That Is Nonresponsive to Inducers of Systemic Acquired Resistance.一种对系统获得性抗性诱导剂无反应的拟南芥突变体的特征分析。
Plant Cell. 1994 Nov;6(11):1583-1592. doi: 10.1105/tpc.6.11.1583.

将PR基因表达与NPR1及细菌抗性解偶联：拟南芥显性突变体cpr6-1的特性分析

Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant.

作者信息

Clarke J D, Liu Y, Klessig D F, Dong X

机构信息

Developmental, Cell, and Molecular Biology Group, Department of Botany, Box 91000, Duke University, Durham, North Carolina 27708-1000, USA.

出版信息

Plant Cell. 1998 Apr;10(4):557-69. doi: 10.1105/tpc.10.4.557.

DOI:10.1105/tpc.10.4.557
PMID:9548982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC144011/
Abstract

In Arabidopsis, NPR1 mediates the salicylic acid (SA)-induced expression of pathogenesis-related (PR) genes and systemic acquired resistance (SAR). Here, we report the identification of another component, CPR 6, that may function with NPR1 in regulating PR gene expression. The dominant CPR 6-1 mutant expresses the SA/NPR1-regulated PR genes (PR-1, BGL 2, and PR-5) and displays enhanced resistance to Pseudomonas syringae pv maculicola ES4326 and Peronospora parasitica Noco2 in the absence of SAR induction. cpr 6-1-induced PR gene expression is not suppressed in the cpr 6-1 npr1-1 double mutant but is suppressed when SA is removed by salicylate hydroxylase. Thus, constitutive PR gene expression in cpr 6-1 requires SA but not NPR1. In addition, resistance to P. s. maculicola ES4326 is suppressed in the cpr 6-1 npr1-1 double mutant, despite expression of PR-1, BGL 2, and PR-5. Resistance to P. s. maculicola ES4326 must therefore be accomplished through unidentified antibacterial gene products that are regulated through NPR1. These results show that CPR 6 is an important regulator of multiple signal transduction pathways involved in plant defense.

摘要

在拟南芥中，NPR1介导水杨酸（SA）诱导的病程相关（PR）基因的表达以及系统获得性抗性（SAR）。在此，我们报告了另一个组分CPR 6的鉴定，它可能与NPR1共同作用来调节PR基因的表达。显性CPR 6 - 1突变体表达SA/NPR1调节的PR基因（PR - 1、BGL 2和PR - 5），并且在没有SAR诱导的情况下，对丁香假单胞菌番茄致病变种ES4326和寄生霜霉Noco2表现出增强的抗性。在cpr 6 - 1 npr1 - 1双突变体中，cpr 6 - 1诱导的PR基因表达未被抑制，但当水杨酸被水杨酸羟化酶去除时则被抑制。因此，cpr 6 - 1中PR基因的组成型表达需要SA而不是NPR1。此外，尽管PR - 1、BGL 2和PR - 5表达，但在cpr 6 - 1 npr1 - 1双突变体中对丁香假单胞菌番茄致病变种ES4326的抗性被抑制。因此，对丁香假单胞菌番茄致病变种ES4326的抗性必须通过由NPR1调节的未知抗菌基因产物来实现。这些结果表明，CPR 6是植物防御中涉及的多个信号转导途径的重要调节因子。