多种体外试剂对大鼠脑内高肌肽-肌肽合成酶的影响。
The effects of various agents in vitro on homocarnosine-carnosine synthetase from rat brain.
作者信息
Ng R H, Marshall F D
出版信息
Experientia. 1976;32(7):839-41. doi: 10.1007/BF02003717.
PMID:954961
Abstract
The present paper reports the first evidence that homocarnosine-carnosine synthetase from rat brain requires free sulfhydryl groups for activity. The activity of the synthetase can be stabilized by dithioerythritol and inhibited strongly by Cu2+, Cd2+, Hg2+, Zn2+, and to a lesser extent by Ca2+, Ni2+, Li, chlorpromazine, alpha-methyl DOPA and norepinephrine at the concentrations tested.
摘要
本文报道了首个证据，即大鼠脑内的高肌肽-肌肽合成酶的活性需要游离巯基。在测试浓度下，二硫苏糖醇可稳定该合成酶的活性，而Cu2+、Cd2+、Hg2+、Zn2+会强烈抑制其活性，Ca2+、Ni2+、Li、氯丙嗪、α-甲基多巴和去甲肾上腺素的抑制作用稍弱。
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