Papakonstantinou-Garoufalias S, Filippatos E, Todoulou O, Tsantili-Kakoulidou A, Papadaki-Valiraki A, De Clerco E, Lada-Chytiroglou A
University of Athens, Department of Pharmacy, Greece.
Farmaco. 1997 Nov;52(11):707-10.
A series of new 1H-1,2,4-triazole derivatives was synthesized and evaluated as potential antiviral (i.e. anti-influenza virus), antibacterial and antifungal agents. The lipophilicity of the compounds was also investigated using calculation procedures. Among the test compounds none showed specific activity against influenza virus, although compound 3a, the most hydrophilic member of the series, showed weak activity against Bacillus subtillis.
合成了一系列新型1H-1,2,4-三唑衍生物，并作为潜在的抗病毒（即抗流感病毒）、抗菌和抗真菌剂进行了评估。还使用计算程序研究了这些化合物的亲脂性。在测试化合物中，没有一种对流感病毒表现出特异性活性，尽管该系列中亲水性最强的化合物3a对枯草芽孢杆菌表现出微弱活性。
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