Knerer B, Matula C, Youssefzadeh S, Ulrich W, Swoboda H
Department of Otorhinolaryngology, Head and Neck Surgery, University of Vienna, Austria.
Eur Arch Otorhinolaryngol. 1998;255(2):57-61. doi: 10.1007/s004050050018.
A recurrence of a primary carcinoid tumor of the middle ear 15 years after radical tympanomastoidectomy is reported. An extended subtotal petrosectomy using a craniocervical approach with temporary infracondylar mandibulotomy was performed, since imaging studies demonstrated an extensive tumor with a close relationship to the tegmen tympani, facial nerve, and ascending and horizontal portions of the carotid canal. The tumor was metabolically inactive. Histopathological examination showed a solid, trabecular tumor that was positive for pancytokeratin Lu5, neuron-specific enolase, pancreatic intestinal polypeptide and glucagon. Neuroendocrine-granules were demonstrable under electron microscopy. This case is reported to show that primary middle-ear carcinoid tumors can recur years after radical tympanomastoidectomy.
报告了1例中耳原发性类癌瘤在根治性鼓室乳突切除术后15年复发的病例。由于影像学研究显示肿瘤广泛,与鼓室盖、面神经以及颈动脉管升段和水平段关系密切,因此采用颅颈入路并临时行髁下下颌骨切开术进行了扩大的次全岩骨切除术。肿瘤代谢不活跃。组织病理学检查显示为实性、小梁状肿瘤,全细胞角蛋白Lu5、神经元特异性烯醇化酶、胰高血糖素和胰多肽呈阳性。电镜下可见神经内分泌颗粒。报道该病例是为了表明原发性中耳类癌瘤可在根治性鼓室乳突切除术后数年复发。