Antoni G, Marsili I, Tarli P, Neri P
Experientia. 1976 Aug 15;32(8):971-2. doi: 10.1007/BF01933917.
Treatment of Cholera toxin with pancreatic elastase and papain in vitro showed a high resistance of the toxin molecule to these enzymes, under non-denaturing conditions or in the presence of 2 M urea. These experiments support the hypothesis of a particularly stable molecular structure of the toxin, as an explanation of its activity in the intestinal lumen where the pancreatic proteases are active.
在体外使用胰弹性蛋白酶和木瓜蛋白酶处理霍乱毒素，结果显示在非变性条件下或存在2M尿素的情况下，毒素分子对这些酶具有高度抗性。这些实验支持了毒素分子具有特别稳定的分子结构这一假说，以此来解释其在胰腺蛋白酶活跃的肠腔中的活性。
