Lulli P, Grammatico P, Brioli G, Catricalà C, Morellini M, Roccella M, Mariani B, Pennesi G, Roccella F, Cappellacci S, Trabace S
Dipartimento di Medicina Sperimentale e Patologia, Università di Roma La Sapienza, Rome, Italy.
Tissue Antigens. 1998 Mar;51(3):276-80. doi: 10.1111/j.1399-0039.1998.tb03102.x.
Controversial data have been reported about HLA alleles and susceptibility to melanoma. Our investigation was undertaken to analyze the relationship between HLA alleles distribution in patients with melanoma and susceptibility to the tumor, in order to study the possible correlation between HLA class II DQA1, DQB1 and DRB1 genes involved in immune recognition, and melanoma, usually considered a highly immunogenic tumor. We therefore typed by means of PCR-SSP (sequence-specific primers) 53 Italian patients and 53 healthy random controls coming from the same geographic area. We observed a decrease of all haplotypes bearing DQB10301, DQB10302 and DQB10303 alleles but not of haplotype DRB111;DQA10501;DQB10301. Our results seem to support the hypothesis of a protective role of some DQ3-bearing haplotypic combinations in melanoma.
关于HLA等位基因与黑色素瘤易感性的报道存在争议。我们进行了这项调查，以分析黑色素瘤患者中HLA等位基因分布与肿瘤易感性之间的关系，以便研究参与免疫识别的HLA II类DQA1、DQB1和DRB1基因与通常被认为是高度免疫原性肿瘤的黑色素瘤之间可能的相关性。因此，我们采用PCR-SSP（序列特异性引物）对来自同一地理区域的53名意大利黑色素瘤患者和53名健康随机对照进行了基因分型。我们观察到携带DQB10301、DQB10302和DQB10303等位基因的所有单倍型均减少，但DRB111;DQA10501;DQB10301单倍型未减少。我们的结果似乎支持某些携带DQ3的单倍型组合在黑色素瘤中具有保护作用这一假说。
