Monguzzi R, Libassi G, Pinza M, Pifferi G
Farmaco Sci. 1976 Aug;31(8):549-60.
The synthesis of some alpha-hydrazinoarylacetic acids (I) by reaction of alpha-bromoarylacetic acids with hydrazine, alkylhydrazines and carbobenzyloxyhydrazines is described. Reduction of the hydrazones of 2- and 3-thienylglyoxylic acids provided a general and effective route to the thienylic series. In view of the use of compounds (I) for the preparation of new penicillins, the experimental conditions for their conversion into cyclohexylamides (XI) via the corresponding carbobenzyloxyderivatives (III) were also investigated.
描述了通过α-溴代芳基乙酸与肼、烷基肼和苄氧羰基肼反应合成一些α-肼基芳基乙酸（I）。2-和3-噻吩基乙醛酸腙的还原为噻吩系列提供了一条通用且有效的路线。鉴于化合物（I）用于制备新型青霉素，还研究了它们通过相应的苄氧羰基衍生物（III）转化为环己基酰胺（XI）的实验条件。
