非吸烟老年人的体重指数与死亡率：心血管健康研究
Body mass index and mortality in nonsmoking older adults: the Cardiovascular Health Study.
作者信息
Diehr P, Bild D E, Harris T B, Duxbury A, Siscovick D, Rossi M
机构信息
Department of Biostatistics, University of Washington, Seattle 98195, USA.
出版信息
Am J Public Health. 1998 Apr;88(4):623-9. doi: 10.2105/ajph.88.4.623.
OBJECTIVES
This study assesses the relationship of body mass index to 5-year mortality in a cohort of 4317 nonsmoking men and women aged 65 to 100 years.
METHODS
Logistic regression analyses were conducted to predict mortality as a function of baseline body mass index, adjusting for demographic, clinical, and laboratory covariates.
RESULTS
There was an inverse relationship between body mass index and mortality; death rates were higher for those who weighed the least. Inclusion of covariates had trivial effects on these results. People who had lost 10% or more of their body weight since age 50 had a relatively high death rate. When that group was excluded, there was no remaining relationship between body mass index and mortality.
CONCLUSIONS
The association between higher body mass index and mortality often found in middle-aged populations was not observed in this large cohort of older adults. Over-weight does not seem to be a risk factor for 5-year mortality in this age group. Rather, the risks associated with significant weight loss should be the primary concern.
目的
本研究评估了4317名年龄在65至100岁之间的非吸烟男性和女性队列中体重指数与5年死亡率之间的关系。
方法
进行逻辑回归分析，以预测死亡率作为基线体重指数的函数，并对人口统计学、临床和实验室协变量进行调整。
结果
体重指数与死亡率呈负相关；体重最轻的人的死亡率更高。纳入协变量对这些结果影响甚微。自50岁起体重减轻10%或更多的人死亡率相对较高。排除该组后，体重指数与死亡率之间不再存在关联。
结论
在这个大型老年人群队列中，未观察到中年人群中常见的较高体重指数与死亡率之间的关联。超重似乎不是该年龄组5年死亡率的危险因素。相反，与显著体重减轻相关的风险应成为主要关注点。
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