Urry R L, Dougherty K A, Cockett A T
Fertil Steril. 1976 Aug;27(8):937-44. doi: 10.1016/s0015-0282(16)42022-4.
The effects of vasectomy on the development and maintenance of spermatogenesis was studied using immature and mature dog testes. Bilateral vasectomy in immature dogs delayed the development of advanced spermatocytes, spermatids, and spermatozoa for about 3 months postsurgery. Spermatogenesis appeared to be recovered to control levels by 4 months postvasectomy. Spermatogenesis in mature dogs was also altered after bilateral vasectomy. Decreased numbers of advanced spermatocytes as well as maturation arrest was observed by 3 weeks postvasectomy. Seminiferous tubule cell layers quickly decreased to one to three layers as the lumina became occluded with sloughed cells by 3 to 6 weeks postvasectomy. Recovery in terms of the numbers of spermatocytes, spermatids, and spermatozoa was evident by 13 weeks postvasectomy, although occasional dog testes did not recover and appeared to be more sensitive to vasectomy-induced damage. It thus appears that vasectomy temporarily inhibits both the development and maintenance of spermatogenesis in immature as well as mature dog testes. Spermatogenesis does recover but may be maintained at somewhat lower levels after vasectomy. Changes are rapid in onset and take several weeks to be reversed. Some dog testes appear to be more sensitive to the damage and it may be irreversible in these testes.
利用未成熟和成熟犬的睾丸，研究了输精管切除术对精子发生的发育和维持的影响。未成熟犬双侧输精管切除术后，高级精母细胞、精子细胞和精子的发育延迟约3个月。输精管切除术后4个月，精子发生似乎恢复到对照水平。成熟犬双侧输精管切除术后精子发生也发生改变。输精管切除术后3周，观察到高级精母细胞数量减少以及成熟停滞。输精管切除术后3至6周，随着管腔被脱落细胞阻塞，生精小管细胞层数迅速减少至1至3层。输精管切除术后13周，精母细胞、精子细胞和精子数量明显恢复，尽管偶尔有犬的睾丸未恢复，且似乎对输精管切除术引起的损伤更敏感。因此，输精管切除术似乎会暂时抑制未成熟和成熟犬睾丸中精子发生的发育和维持。精子发生确实会恢复，但输精管切除术后可能会维持在略低的水平。变化开始迅速，需要数周才能逆转。一些犬的睾丸似乎对损伤更敏感，在这些睾丸中可能是不可逆的。
