重组活流感疫苗的制备与特性研究
Preparation and characterization of live recombinant influenza vaccine.
作者信息
Stealey V M, McCahon D, Freestone D S
出版信息
Dev Biol Stand. 1976;33:191-6.
PMID:955267
Abstract
Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.
摘要
WRL 105株是通过先前描述的方法，由A/芬兰/4/74（H3N2）和减毒的A/奥田/57（H2N2）株重组制备而成。向志愿者以三个剂量水平鼻内单次接种WRL 105株减毒活流感疫苗，并监测同源血清抗体滴度和病毒排泄情况。剂量大于10(6.3)EID50时，80%的血清阴性志愿者的抗体滴度升高了4倍或更高。
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